Chicken Spinach Casserole

Featured in main-dishes.

Hey friend, you're going to absolutely love making this casserole! Picture this: tender chicken nestled in a bed of wilted spinach, all swimming in the most luscious, garlicky cream sauce you've ever tasted. The mushrooms add this incredible earthy depth, and that golden, bubbly cheese on top? Pure magic. What I love most is how the kitchen fills with the most amazing aroma while it bakes – it's like a warm hug for your senses. The best part? You can prep everything in one dish, pop it in the oven, and relax while it transforms into this gorgeous, restaurant-worthy meal. When you pull it out, that golden-brown top with the melted cheese creating those perfect crispy edges... trust me, everyone's going to crowd around the kitchen asking when dinner's ready. It's comfort food at its absolute finest, and you're going to nail it!

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Updated on Tue, 23 Dec 2025 22:40:45 GMT
Main recipe image showcasing the final dish pin it
Golden-brown creamy chicken and spinach casserole with melted cheese in white baking dish | lonerecipes.com

I first discovered this recipe during a potluck dinner at a friend's house about five years ago. Someone brought this incredible casserole that had everyone going back for seconds, and I knew I had to recreate it. The dish itself is a beautiful harmony of textures and flavors – you've got the tender, juicy chicken pieces that soak up all that creamy goodness, the spinach that wilts down and adds this lovely earthiness, and the mushrooms that bring an umami depth to every bite. What really makes this casserole special is the cream sauce – it's infused with garlic and becomes this velvety blanket that coats everything. The cheese on top creates this gorgeous golden crust that's slightly crispy around the edges but stays gooey in the center. When you scoop into it, you get layers of flavor in every bite. The spinach provides a pop of color and nutrition, making you feel a little less guilty about all that cream and cheese. It's the kind of dish that looks impressive when you serve it, but honestly, it's so simple to put together that I make it on regular weeknights. The best part is watching it transform in the oven from this pale mixture to a golden, bubbling masterpiece.

Why I love this recipe

There are so many reasons why this casserole has become a staple in my kitchen. First, it's incredibly versatile – I can prep it in the morning, keep it in the fridge, and just pop it in the oven when I get home from work. The ingredient list is straightforward, and I usually have everything on hand, which means no last-minute grocery runs. What I really appreciate is how it manages to be both indulgent and somewhat nutritious – yes, there's cream and cheese, but you're also getting a good amount of protein from the chicken and all those vitamins from the spinach. My kids actually eat their greens when they're smothered in this creamy sauce! The leftovers are fantastic too; they reheat beautifully and sometimes taste even better the next day when all the flavors have melded together. I love that this recipe feeds a crowd without breaking the bank – it's budget-friendly but tastes like something you'd order at a fancy restaurant. The comfort factor is huge for me too. On cold evenings or when I'm feeling stressed, making this casserole is almost therapeutic, and eating it is like getting a warm hug from the inside. It's become one of those recipes I'm known for among family and friends.

What You Need From Your Kitchen

  • Chicken breasts: Cut into bite-sized cubes and season with salt and pepper before searing until golden brown
  • Fresh spinach: Wash thoroughly and add to the skillet to wilt down with the mushrooms and garlic
  • Mozzarella cheese: Shred fresh and divide into two portions – half for the sauce and half for topping
  • Heavy cream: Use full-fat cream for the richest, most luxurious sauce that coats everything perfectly
  • Mushrooms: Slice evenly and sauté until they release their moisture and develop a golden color
  • Garlic: Mince finely and sauté until fragrant to infuse the entire dish with aromatic flavor

Let's Make These Together

Prepare the chicken
Start by cutting your chicken breasts into uniform cubes, about 1-inch pieces work perfectly. This ensures even cooking and makes the casserole easier to serve. Season them generously with salt, pepper, and Italian herbs. Heat olive oil in your largest skillet and sear the chicken in batches if needed, making sure not to overcrowd the pan. You want a nice golden-brown color on the outside, which adds incredible flavor to the final dish.
Sauté the vegetables
Using the same skillet with all those delicious browned bits from the chicken, add your mushrooms. Let them cook undisturbed for a couple minutes to develop that beautiful golden color. Then add the garlic and let it bloom in the hot pan – you'll know it's ready when that amazing aroma fills your kitchen. Finally, add your spinach and watch it wilt down dramatically. This is where the magic starts to happen as all these flavors begin to meld together.
Create the creamy sauce
Pour in the heavy cream and let it come to a gentle simmer. This is where the sauce starts to thicken and become absolutely luxurious. Stir in your cheeses gradually, watching them melt into the cream and create this gorgeous, velvety sauce. Don't rush this step – let the cheese melt completely and the sauce thicken to the perfect consistency. Taste it and adjust your seasonings. This is your moment to make it perfect.
Assemble and bake
Transfer your seared chicken to your prepared baking dish, spreading it out in an even layer. Pour that incredible creamy spinach and mushroom sauce over the top, making sure every piece of chicken is covered. Top it all off with the remaining mozzarella. Cover with foil and let it bake until everything comes together. Then remove the foil for that final blast of heat that creates the golden, bubbly, irresistible top that everyone fights over.
Additional recipe photo showing texture and details pin it
Homemade creamy chicken spinach bake with herbs and melted mozzarella in ceramic dish | lonerecipes.com

Switch Things Up

I remember the first time I made this casserole on a particularly busy Tuesday evening. I was tired from work and needed something comforting but didn't have the energy for anything complicated. I threw together what I had in the fridge – some chicken, a bag of spinach that needed using, and cream cheese. The smell that filled my kitchen as it baked was absolutely incredible. When I pulled it out of the oven, that golden, bubbly top looked so inviting. My family couldn't wait to dig in, and the first bite was pure comfort. The creamy sauce, the tender chicken, the earthy spinach – everything just worked perfectly together. Since then, I've probably made this casserole at least fifty times. Sometimes I add extra mushrooms, other times I throw in some sun-dried tomatoes. What I love most is how forgiving this recipe is – you can adapt it to whatever you have on hand, and it always turns out delicious.

Perfect Pairings

This casserole pairs beautifully with a crisp green salad dressed with a light vinaigrette to cut through the richness. Garlic bread or crusty French bread is perfect for soaking up that creamy sauce – trust me, you won't want to waste a drop! For a complete meal, serve it alongside roasted vegetables like asparagus or green beans. If you're feeling fancy, a glass of Chardonnay or Sauvignon Blanc complements the creamy, garlicky flavors wonderfully. For a heartier spread, wild rice or quinoa pilaf makes an excellent side dish that adds texture and keeps the meal balanced.

Step-by-step preparation photo pin it
Bubbling hot chicken casserole with fresh spinach and mushrooms topped with golden cheese | lonerecipes.com

Frequently Asked Questions

→ Can I use frozen spinach instead of fresh?

Yes, you can use frozen spinach as a substitute. You'll need about 10 ounces of frozen spinach. Make sure to thaw it completely and squeeze out as much water as possible before adding it to the recipe, otherwise your casserole will be watery. Fresh spinach gives better texture, but frozen works in a pinch.

→ How do I know when the chicken is fully cooked?

The chicken is done when it reaches an internal temperature of 165°F (74°C). You can check this with a meat thermometer inserted into the thickest piece. The chicken should also be opaque throughout with no pink remaining. Since the chicken continues cooking in the oven after being seared, it will be perfectly cooked through by the end of the baking time.

→ Can I make this casserole ahead of time?

Absolutely! This casserole is perfect for meal prep. You can assemble everything completely, cover it tightly with plastic wrap and foil, and refrigerate for up to 24 hours before baking. When you're ready to cook, remove it from the fridge while the oven preheats and add about 10 extra minutes to the covered baking time since it's starting cold.

→ What can I substitute for heavy cream?

If you want a lighter option, you can use half-and-half, though the sauce won't be quite as rich. You could also try a mixture of milk and cream cheese for thickness. For a dairy-free version, coconut cream works surprisingly well and adds a subtle sweetness that complements the savory flavors. Avoid using just milk as it won't create the same creamy, thick sauce.

→ How should I store and reheat leftovers?

Store leftovers in an airtight container in the refrigerator for up to 4 days. To reheat, you can microwave individual portions for 2-3 minutes, stirring halfway through. For larger portions, reheat in a covered dish in a 350°F oven for about 20 minutes. You might want to add a splash of cream or milk when reheating to keep the sauce from drying out.

→ Can I freeze this casserole?

Yes, this casserole freezes well! You can freeze it either before or after baking. If freezing unbaked, assemble everything, wrap tightly in plastic wrap and foil, and freeze for up to 3 months. Thaw overnight in the refrigerator before baking as directed. If freezing after baking, let it cool completely, portion it out, and freeze in airtight containers for up to 2 months. Thaw and reheat in the oven.

Conclusion

This Creamy Chicken and Spinach Casserole is the ultimate comfort food that brings the whole family together. The combination of tender chicken, nutritious spinach, and that irresistibly creamy sauce creates a meal that's both satisfying and wholesome. Whether you're serving it for a weeknight dinner or a special gathering, this casserole never fails to impress. The leftovers are just as delicious the next day, making it perfect for meal prep. Give it a try, and it might just become your new favorite go-to recipe!

Chicken Spinach Casserole

A rich and creamy baked casserole featuring tender chicken, fresh spinach, mushrooms, and melted mozzarella in a velvety garlic cream sauce.

Prep Time
20 Minutes
Cook Time
35 Minutes
Total Time
55 Minutes
By: chris

Category: main-dishes

Difficulty: easy

Cuisine: American

Yield: 6 Servings (6 balls)

Dietary: Meat, Gluten-Free

Ingredients

014 boneless chicken breasts, cubed
023 cups fresh spinach
032 cups mozzarella cheese, shredded
041 cup heavy cream
058 oz mushrooms, sliced
064 cloves garlic, minced
071/2 cup parmesan cheese, grated
082 tablespoons olive oil
09Fresh parsley for garnish

Instructions

Step 01

Preheat your oven to 375°F (190°C). Cut the chicken breasts into bite-sized cubes and season them with salt, pepper, and a pinch of Italian seasoning. Heat olive oil in a large skillet over medium-high heat and sear the chicken pieces until they're golden brown on all sides, about 5-6 minutes. You don't need to cook them all the way through since they'll finish in the oven. Transfer the chicken to a greased 9x13 inch baking dish.

Step 02

In the same skillet, add the sliced mushrooms and cook them for about 4-5 minutes until they release their moisture and start to brown. Add the minced garlic and sauté for another minute until fragrant. Then add the fresh spinach and cook until it wilts down, about 2-3 minutes. The spinach will reduce significantly in volume, which is exactly what you want.

Step 03

Pour the heavy cream into the skillet with the vegetables and stir everything together. Let it simmer for 2-3 minutes until it thickens slightly. Add half of the mozzarella cheese and all of the parmesan, stirring until the cheese melts and creates a smooth, creamy sauce. Season with salt, pepper, and a pinch of nutmeg if you like. Taste and adjust seasonings as needed.

Step 04

Pour the creamy spinach and mushroom mixture over the chicken in the baking dish. Use a spatula to spread it evenly, making sure all the chicken pieces are covered with the sauce. Sprinkle the remaining mozzarella cheese over the top, creating an even layer that will turn golden and bubbly as it bakes.

Step 05

Cover the baking dish with aluminum foil and bake for 25 minutes. Then remove the foil and continue baking for another 10-15 minutes until the cheese on top is golden brown and bubbly, and the chicken is cooked through. Let the casserole rest for 5 minutes before serving. Garnish with fresh chopped parsley for a pop of color and freshness.

Notes

  1. You can substitute chicken thighs for chicken breasts if you prefer darker meat – they'll add even more flavor and stay incredibly juicy.
  2. Fresh spinach works best for this recipe, but in a pinch, you can use frozen spinach. Just make sure to thaw it completely and squeeze out all the excess water before adding it to the skillet.
  3. Feel free to add other vegetables like sun-dried tomatoes, artichoke hearts, or bell peppers for extra flavor and nutrition.
  4. This casserole can be assembled ahead of time and refrigerated for up to 24 hours before baking. Just add an extra 10 minutes to the covered baking time if you're starting from cold.
  5. Leftovers keep well in the refrigerator for up to 4 days and reheat beautifully in the microwave or oven.

Tools You'll Need

  • 9x13 inch baking dish
  • Large skillet or frying pan
  • Sharp knife and cutting board
  • Wooden spoon or spatula
  • Measuring cups and spoons
  • Aluminum foil
  • Cheese grater

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Dairy (cream, mozzarella cheese, parmesan cheese)
  • Garlic (for sensitive individuals)
  • Mushrooms (for those with fungus allergies)

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 425
  • Total Fat: 28 g
  • Total Carbohydrate: 9 g
  • Protein: 38 g

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